Andrographolide sensitizes human renal carcinoma cells to TRAIL‑induced apoptosis through upregulation of death receptor 4. Clipboard, Search History, and several other advanced features are temporarily unavailable. 1999 Jun 18;274(25):17484-90. doi: 10.1074/jbc.274.25.17484. tBID is the active from of the protein and it redistributes from the CYTOSOL to MITOCHONDRIA to promote release of CYTOCHROME C.

This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. Mutagenesis study indicated that the BH3 domain is required for the apoptotic activity of BID since BID with an intact BH3 domain may retain interaction with BAX [4][5]. Bid, therefore, relays an apoptotic signal from the cell surface to mitochondria. 1. In healthy cells BID is cytosolic.

Peptide mass fingerprinting identified this protein as Bid, a BH3 domain-containing protein known to interact with both Bcl2 and Bax.

High purity, Low endotoxin, Multiple Tags, Animal-free, Wide applications (Cell assay, Protein-protein interaction, Drug-related studies, Enzymatic activity in vitro, Protein structure analysis, etc.)  | Last modifications, Copyright © 2012 sensagent Corporation: Online Encyclopedia, Thesaurus, Dictionary definitions and more. Cell Death Differ 2001; 7: 1166-173. Get XML access to reach the best products. Description. ○   Boggle. 1998; 18: 6083-6089. The production of BAX and BAK further leads to cytochrome c release into the cytoplasm, following caspase activation and apoptosis [6]. Sheng H, Lv W, Zhu L, Wang L, Wang Z, Han J, Hu J. Int J Mol Med. Immunoblot analysis was performed with a horseradish peroxidase conjugated goat anti-rabbit (Bid), or goat anti-mouse (cytochrome c, cytochrome c oxidase), immunoglobulin G using enhanced chemiluminescence Western blotting detection reagents …

EGFR|BCMA|CD44|TROP2|PD-L1|CD276|ACE2|TMPRSS2|Exosome Isolation Kits. Cell. tBID is the active from of the protein and it redistributes from the CYTOSOL to MITOCHONDRIA to promote release of CYTOCHROME C. BH3 Interacting Domain Death Agonist Protein, Anti-Apoptotic Proteins, Apoptosis Inducing Proteins, Apoptosis Inhibiting Proteins, Apoptosis Regulatory Proteins, Death Factors (Apoptosis), Pro-Apoptotic Proteins, Programmed Cell Death Proteins, Survival Factors (Apoptosis), Cellular Proto-Oncogene Proteins, c-onc Proteins, Proto-Oncogene Products, Cellular, Proto-Oncogene Proteins, Proto Oncogene Proteins, Cellular, bcl-2 Genes, c-bcl-2 Genes, c-bcl-2 Proto-Oncogenes, Genes, bcl-2, bcl-2 Proto-Oncogene Proteins, Proto-Oncogene Proteins c-bcl-2, an offensive content(racist, pornographic, injurious, etc. Get XML access to fix the meaning of your metadata. 1998; 94: 481-490. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis [J]. BID possesses a single BH3 (Bcl-2 homology 3) domain and lacks a C-terminal transmembrane domain for the outer mitochondrial membrane[1]. Bid, a critical mediator for apoptosis induced by the activation of Fas/TNF-R1 death receptors in hepatocytes.

Korsmeyer SJ, Gross A, Harada H, Zha J, Wang K, Yin XM, Wei M, Zinkel S. Cold Spring Harb Symp Quant Biol.