The metro area population of Manisa in 2017 was 354,000, a 2.61% increase from 2016. Today Manisa's economic activities are far from being confined to a sole company. This practice was discontinued in 1595, largely due to the growing insecurity in the countryside, precursor of Jelali Revolts, and a violent earthquake dealt a severe blow to the Manisa region's prosperity the same year. In the early 13th century the region of Magnesia was subject to repeated raids by invading Turkish bands. Cybele monument by itself represents a step of innovation in Hittite art where full-faced figures in high relief are rare. Manisa registered roughly 200m US dollars in FDI in 2004 and well-known businesses such as Italian white goods company Indesit, German electrical goods company Bosch, UK packaging company Rexam and Imperial Tobacco of the UK have invested in Manisa. In classical antiquity, Romans knew the city as Magnesia ad Sipylum. Manisaspor's home ground is the Manisa 19 Mayis Stadi.

Historically, the city was also called Magnesia (Greek: Μαγνησία), and more precisely as Magnesia ad Sipylum to distinguish from Magnesia on the Maeander at a relatively short distance to the south. The vestiges from their capital which reached our day bring together remains from several successive civilizations. The name is rendered as Μαγνησία in ancient and modern Greek language. Manisa Urban Area Population Projections.
Manisa (Turkish pronunciation: [maˈnisa]), historically known as Magnesia, Greek: Μαγνγησια, is a large city in Turkey's Aegean Region and the administrative seat of Manisa Province. The Muradiye Mosque of the 16th century was built by the great architect Mimar Sinan (and completed by Sedefkar Mehmed Agha), and the 'Murad Bey Medresse now houses the Archaeological Museum of Manisa. The highest numbers of workforce are concentrated in electronics/electrical appliances, foodstuffs and construction industries. The Ottoman Turkish form of the name "Manisa" (ماغنيسا) was usually as it is still used presently, but a spelling with a longer first syllable, transcribed to modern Turkish as "Mağnisa", was also occasionally encountered. Manisa and some of its depending district centers have succeeded in solidly clinching an industrial production base in recent decades, in this supported both initially and continuously by the century-old wide-scale agricultural processing and related activities (production of flour and olive oil, basic textiles, leather goods, agricultural tools and instruments, cotton ginning). The splendid synagogue from the 3rd century is worth visiting, with its elaborate mosaics and artfully carved colored-stone panels. Traces of prehistory in the Manisa region, although few in number, nevertheless include two very interesting finds that shed much light on western Anatolia's past. The city of Manisa is the seat and capital of the province.

Modern Manisa is a booming center of industry and services, advantaged by its closeness to the international port city and the regional metropolitan center of İzmir and by its fertile hinterland rich in quantity and variety of agricultural production. Large parts of the population had begun settling and becoming sedentary and the city was a point of terminus for caravans from the east, with İzmir's growth still in its early stages. There are the remains of the temple of Artemis and a restored gymnasium, exhibiting of the past splendor of this ancient city. In her honor, Mesir Festival (featuring the "Mesir Paste" (Turkish: Mesir Macunu), a spiced paste in the form of candy, and claimed to restore health, youth and potency, is held every year in March, in the grounds of this mosque, and is an occasion for public gathering as well as attendance by personalities of fame and prominence at national scale. The historic part of Manisa spreads out from a forested valley in the immediate slopes of Sipylus mountainside, along Çaybaşı Stream which flows next to Niobe's "Weeping Rock" ("Ağlayan Kaya"), an ancient bridge called the "Red Bridge" ("Kırmızı Köprü") as well as to several tombs-shrines in the Turkish style dating back to the Saruhan period (14th century). Price sold the whole network in 1893 to the Franco-Belgian group Compagnie Internationale des Wagons-Lits, which extended it further east to Afyonkarahisar in 1896 and further north to Bandırma in 1912.

This railway was the third started within the territory of the Ottoman Empire at the time and the first finished within the present-day territory of Turkey. [8] The local population was unable to repulse the Turkish raids.

The first millennium BC saw the emergence in the region of "Phrygians" and "Maeonians", the accounts concerning which are still blended with myths,[a] and finally of Lydians.

A connection with native Anatolian languages has also been suggested of recent date, particularly on the basis of discoveries made in the Hittite archives treating the Luwian western Anatolia. In 1076 the Byzantine Empire lost the city to the Seljuks in the aftermath of the 1071 Battle of Manzikert.The subsequent Crusader victory at the Battle of Dorylaeum (1097) allowed the Byzantine Emperor Alexios I to recover Magnesia.